FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids

Figure 1

Ffar4 HET and KO mice are protected against obesity development on a high fat ω3-PUFA diet. Mice were scaled weekly from 6 weeks of age; experimental diets were initiated when mice were 11 weeks old. ((a)–(f)) Heterozygotes. ((g)–(l)) Knockouts. ((a) and (g)) Weight development, –8. ((b) and (h)) Lean mass from MR scans 32 weeks after diet initiation (43 weeks of age), –8. ((c) and (i)) Fat mass from MR scans 32 weeks after diet initiation, –8. ((d) and (j)) eWAT weights 36 weeks after diet initiation, –8. ((e) and (k)) Liver weights 36 weeks after diet initiation, –8. ((f) and (l)) Feed intake measured two times a week in single-housed mice till 32 weeks after diet initiation, –7. All data are presented as means ± SEM. Both HFDs are compared to the LFD. For (a), (f), (g), and (l) data were Ln-transformed and 2-way RM ANOVA with Bonferroni correction was performed. All data shown in bar graphs were Ln-transformed and subjected to 1-way ANOVA with Bonferroni correction. Only statistical significant differences are shown. , , , and .