Epobis is a Nonerythropoietic and Neuroprotective Agonist of the Erythropoietin Receptor with Anti-Inflammatory and Memory Enhancing Effects

Figure 4

Effects of Epobis on hematopoiesis in vivo. Mice were injected with Epobis (), EPO (), or PBS () twice per week for 5 weeks (black arrowheads). Hematocrit (a, b) and hemoglobin levels (c) were estimated from blood samples taken once per week for 6 weeks; first sample day, 0; last sample day, 42. Data are presented as actual values (a) and normalized to vehicle (PBS) from the same day (100%, b and c). Statistics was performed on nonnormalized data using a one-way ANOVA for repeated measures followed by Tukey’s Multiple Comparison Test. ; ; , Epobis versus vehicle.

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