Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs

Figure 3

The interaction of miR-155, miR-221/222, and miR-126 in regulation of Ets-1 driven endothelial cell inflammation. A variety of proinflammatory extracellular factors induce Ets-1 transcription which subsequently induces expression of EC proteins involved in T-cell recruitment. miR-155 and miR-221/222 act to reduce translation of Ets-1, while miR-126 acts further downstream to reduce VCAM-1 translation.