Innate Immunity Components and Cytokines in Gastric Mucosa in Children with Helicobacter pylori Infection

Table 1

mRNA expression of inflammatory mediators in the gastric mucosa in relation to H. pylori and cagA status.

Gene	Expression in H. pylori infected relative to noninfected patients	P value	Expression in H. pylori cagA(+) relative to H. pylori cagA(−) patients	P value
IL-1β	1.1	0.06	1.5	0.13
IL-2	1.4	0.86	1.4	0.29
IL-6	4.6	<0.01	2.5	0.03
IL-10	6.5	<0.01	3.5	<0.01
IL-12β	1.2	0.56	1.0	0.95
INF-γ	3.4	<0.01	1.6	0.26
TNF-α	5.5	<0.01	1.0	0.25
MyD88	1.4	0.54	0.8	0.67
TLR2	1.7	0.30	1.2	0.58
TLR4	1.5	0.11	1.2	0.48
TREM1	1.4	0.39	1.1	0.4
TREM2	1.4	0.23	1.2	0.31
CD14	1.5	0.43	1.0	0.99
CD163	4.2	<0.01	1.4	0.44

The expression of each gene is given relative to the expression in H. pylori-negative or H. pylori  cagA-negative samples (fold change in log₁₀ RQ).