Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
Figure 3
Ultrastructural changes associated with the necroptotic cell death induced by a combination of TNF-α (10 ng/mL) and z-VAD-fmk (20 μM) in NHI3T3 murine fibroblasts (a diploid cell line). Panel (a) shows a cell with intact organelles and plasma membrane, whereas (b) shows cells with extensive cytoplasmic degeneration and plasma membrane rupture and (c) shows a cell with apoptosis-like chromatin condensation.
