|
| Organism/Cell type | Pathogen bacteria | Receptors involved | Cellular response evaluated |
|
| Human homozygotic macrophages (3020insC mutation) and macrophages from TLR2−/− or WT mice | Mycobacterium tuberculosis | NOD2 and TLR2 | Production of TNF-, IL-1 and IL-6 |
|
| Human homozygotic macrophages (3020insC mutation) and macrophages from TLR2−/−, TLR4−/−, MyD88−/− or WT mice | Mycobacterium paratuberculosis | NOD2, TLR2 and TLR4 | Production of TNF-, IL-1, IL-6 and IL-10 |
|
| Bone marrow-derived macrophages from TLR2−/−, NOD2−/− or WT mice | Streptococcus pneumoniae cell wall (PnCW) | NOD2 and TLR2 | Production of IL-10 |
|
| Mesothelial cells from RICK−/−, NOD1−/− or WT mice | Listeria monocytogenes | NOD1 and TLR2 | Production of CXCL1 and CCL2 |
|
| NOD1−/−, NOD2−/−, RIP2−/− or WT mice | Chlamydophila pneumoniae | NOD1, NOD2, TLR2 and TLR4 | Expression of iNOS, production of NO, IL-6, IL12p40 and IFN-, and bacterial clearance |
|
| NLRC4−/−/TLR5−/− or WT mice | Legionella pneumophila | NLRC4 and TLR5 | Bacterial clearance, recruitment of neutrophils |
|
| MyD88−/−, RIP2−/−, WT mice or with nonfunctional Naip5 gene | Legionella pneumophila | NLRC4, TLR2, TLR5 and TLR9 | Replication and dissemination of bacteria, rates of mortality and production of IL-6 |
|
| NOD1−/−, NOD2−/−, NLRP3−/−, NLRC4−/−, Casp1−/−, Asc−/−, TLR2−/− or WT mice | Helicobacter pylori | NOD2, TLR2 and NLRP3 | Production of IL-1 and NLRP3 activation |
|
| BALB/c mice and human monocyitic leukemia THP-1 | Salmonella enterica serovar Typhimurium | NOD1 and TLR5 | Bacterial clearance and production of IL-5, IL-6, IL-13, IL-21, IL-22, TNF- and -defensin 3 |
|
Dendritic cell
Keratinocytes from oral epithelium | Staphylococcus aureus | NOD2 and TLR2 | Production of IL-6 and IL-1 |
|
| Mice double deficient in Myd−/−Trif−/−
| Vibrio vulnificus and Vibrio cholerae | TLRs and NLRP3 | Activation of NF-B |
|
| Mice and primary monocytes | Pseudomonas aeruginosa | TLR5 and NLRC4 | Autophagy and production of IL-17, IL-18 and Type I IFN |
|
