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Cell type | Chemical agonist used | Receptors involved | Cellular response |
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Human monocytic leukemia THP-1 | iE-DAP and MDP Pam3CSSNA, LA-15-PP, CpG DNA | NOD1 and NOD2 TLR2, 4 and 9 | NF-B activation, IL-8 mRNA expression and secretion of IL-8 |
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Human oral epithelial HSC-2 | FK156 and MDP FSL-1, Poly I:C, LA-15-PP, Poly U and CpG DNA | NOD1 and NOD2 TLR2, 3, 4, 7 and 9 | NF-B activation, and production of PGRPs and -defensin 2 |
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Human embryonic kidney HEK293T and human monocytes | MtriDAP and MDP or MtriLYS Pam3CSK4 and LPS preparations from Escherichia coli O111:B4 | NOD1 and NOD2 TLR2 | Release of TNF-, IL-1, IL-6, and IL-8 |
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Bone marrow-derived mice macrophages | MDP Pam3CSK4, Poly I:C and LPS | NOD2 TLR2, 3 and 4 | Activation of NF-B, p38 and ERK. Production of IL-6 and IL-12p40 |
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Human dendritic cells | FK565 and MDP Poly I:C, LA-15-PP, and CpG DNA | NOD1 and NOD2 TLR3, 4 and 9 | Production of IL-12p70, IL-15, and IFN- |
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Human blood mononuclear cells | MtriDAP LPS, MALP2, Pam3CysLys4, Flagellin from Salmonella typhimurium and R-848 | NOD1 TLR4, 2/6, 1/2, 5 and 7/8 | Secretion of TNF-, IL-1, IL-1, IL-4, IL-6, IL-10, and GM-CSF |
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Human homozygotic macrophages (3020insC mutation) | MDP Pam3Cys and MALP2 | NOD2 TLR2 | Production of TNF-, IL-1, and IL-10 |
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Murine and human CD8 T cells | iE-DAP Pam3CSK4 | NOD1 TLR2 | Activation of NF-B, p38 and JNK Secretion of TNF-, IL-2, and, IFN-ā Induction of cellular proliferation and expansion |
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Monocyte derived-dendritic cells | iE-DAP and MDP LPS and R848 | NOD1 and NOD2 TLR4 and 7/8 | Secretion of IL-1 and IL-23; expression of SOCS2 |
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