The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria

Figure 3

The PI3K/Akt signaling pathway enhances β-catenin activation. In colon epithelial cells infected with Citrobacter rodentium, Akt phosphorylates β-catenin at Ser552. The activation of β-catenin increases c-myc and reduces TNFα and IFNγ expression. An opposite effect is observed in cells incubated with the PI3K inhibitor LY294002.