Mediators of Inflammation

Research Article

Differential Expression of Host Biomarkers in Saliva and Serum Samples from Individuals with Suspected Pulmonary Tuberculosis

Table 4

Utility of host markers detected in serum in the diagnosis of TB disease.


Marker	TB cases	Non-TB cases	value	AUC (95% CI)	Cut-off value	Sensitivity % (95% CI)	Specificity % (95% CI)

IL-6	11.5 (0.0–28.1)	0.0 (0.0-0.0)	0.01	0.73 (0.54–0.92)	>27.54	27.3 (6.0–61.0)	96.3 (81.0–99.9)
IL-2	0.6 (0.0–1.3)	0.0 (0.0-0.0)	0.01	0.73 (0.53–0.92)	>0.95	45.5 (16.8–76.6)	92.6 (75.7–99.1)
SAP	60894.8 (45137.4–65623.2)	42251.4 (36985.9–53804.8)	0.03	0.72 (0.54–0.90)	>58914	54.6 (23.4–83.3)	85.2 (66.3–95.8)
SAA	239.1 (0.0–848.8)	6133.8 (2012.1–40070.2)	0.05	0.70 (0.52–0.88)	>941894	18.2 (2.3–51.8)	96.3 (81.0–99.9)

Median levels (pg/mL) and interquartile ranges (in parenthesis) of the markers and abilities to discriminate between pulmonary TB cases () and individuals without active TB () are shown. Only markers for which Mann-Whitney values were ≤0.09 are shown. AUC: area under the receiver operator characteristics (ROC) curve; 95% CI: 95% confidence interval. The cut-off values are for sensitivity and specificity for TB disease and were selected based on the highest likelihood ratio. Marker levels are in pg/mL except for SAA and SAP (ng/mL).