JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia Cells

Table 1

Effects of fluoride on cell viability in microglial BV-2 cells (the percentage against the control group, %).

NaF (μg/mL)	6 h	12 h	24 h	48 h	72 h
0	100.0 ± 3.6	100.0 ± 1.7	100.0 ± 0.0	100.0 ± 5.1	100.0 ± 0.9
1	107.7 ± 4.6**	100.0 ± 2.1	95.0 ± 1.0**	90.2 ± 3.7**	102.2 ± 3.4
5	106.8 ± 2.2*	98.4 ± 3.5	96.0 ± 1.0**	93.2 ± 3.3*	100.2 ± 3.1
10	102.6 ± 4.5	94.5 ± 1.4*	94.3 ± 1.6*	92.3 ± 1.9*	102.2 ± 3.1
25	101.4 ± 5.6	94.8 ± 5.9**	91.6 ± 5.4**	84.4 ± 5.8**	102.7 ± 2.2
50	100.2 ± 5.1	93.9 ± 2.6*	87.1 ± 4.2**	81.0 ± 5.0**	86.4 ± 1.6**
100	90.3 ± 1.8**	78.1 ± 1.4**	70.7 ± 6.2*	71.8 ± 7.7**	50.2 ± 2.9**
𝑅	−0.517	−0.766	−0.809	−0.826	−0.684
𝑃	0.002	0.000	0.000	0.000	0.000

𝑅: the correlation coefficients; 𝑃: 𝑃 values; ^∗𝑃<0.05 compared with 0 μg/mL group; ^∗∗𝑃<0.01 compared with 0 μg/mL group.