The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts

Table 2

Cohort studies demonstrating no association between oxidized low-density lipoprotein measurement and cardiovascular events.

Oxidative oxLDL test	Population under study	CV endpoints	Number of events	Followup	Findings	Reference
OxLDL Abs 4E06	3033 elderly	CV events	418 IHD, 120 MI	3 years	OxLDL did not predict CV events at MV analysis	Holvoet et al. [95]
AutoAbs MDA-oxLDL	2619 subjects	IHD (angina, ACS, and IHD death); CV events (IHD + TIA/stroke)	151 IHD, 234 CV events	8 years	AutoAbs did not predict CV events	Wilson et al. [99]
OxLDL Abs 4E06, AutoAbs MDA-/Cu-oxLDL	919 subjects	Carotid atherosclerosis progression	na	5 years	AutoAbs and oxLDL did not predict CV events	Mayr et al. [100]
AutoAbs Cu-oxLDL	92 NIDDM, 80 ctr	CV events	34 CV events, 15 CV deaths	10 years	AutoAbs did not predict CV events	Uusitupa et al. [96]
OxLDL Abs 4E06	69 ESRD on hemodialysis, 33 ctr	CV events	18 CV events	43 months	OxLDL did not predict CV events	Lee et al. [101]
AutoAbs Cu-oxLDL	415 IHD	CV events	35 CV deaths/MI, 33 PTCA/CABG	5 years	AutoAbs did not predict CV events	Erkkilä et al. [97]
OxLDL Abs 4E06	687 PTCA pts	Restenosis, CV events	135 restenosis, 181 CV events	1 year	OxLDL did not predict CV events	Braun et al. [98]

Abs: antibodies; AutoAbs: autoantibodies; CABG: coronary artery by-pass surgery; CHF: congestive heart failure; Crt: controls; CV: cardiovascular; ESRD: end-stage renal disease; IHD: ischemic heart disease; IMT: intima-media thickness; MI: myocardial infarction; NIDDM: noninsulin dependent diabetes mellitus; oxLDL: oxidized low-density lipoproteins; PTCA: percutaneous transluminal coronary angioplasty; pts: patients.