Mediators of Inflammation

Review Article

The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts

Table 1

Cohort studies demonstrating an association between oxidized low-density lipoprotein measurement and cardiovascular events.


Oxidative oxLDL test	Population under study	CV endpoints	Number of events	Followup	Findings	Reference

OxLDL Abs 4E06	326 men	IMT	na	3 years	OxLDL predicted IMT and carotid plaque progression	Wallenfeldt et al. [88]

OxLDL Abs 4E06	765 subjects	CV events	77 CV events	5 years	OxLDL predicted CV events	Tsimikas et al. [90]

OxLDL Abs 4E06	765 subjects	CV events	82 CV events	10 years	OxLDL predicted CV events	Kiechl et al. [92]

OxPL/apoB, AutoAbs MDA-/Cu-oxLDL	765 subjects	CV events	138 CV events	15 years	OxPL/apoB predicted CV events and stroke; AutoAbs predicted CV events, stroke, and ACS	Tsimikas et al. [94]

MDA-LDL	907 NIDDM	CV events, MI	152 CV events, 43 MI	3.7 years	MDA-LDL predicted MI and CV events	Lopes-Virella et al. [93]

AutoAbs Cu-oxLDL	249 ESRD	CV mortality	74 CV deaths	63 months	AutoAbs predicted CV mortality	Shoji et al. [84]

AutoAbs Cu-oxLDL	94 ESRD on hemodialysis	Total mortality	32 deaths	24 months	AutoAbs predicted mortality	Bays et al. [85]

AutoAbs Cu-oxLDL	94 ESRD on hemodialysis	CV mortality	33 CV deaths	4 years	AutoAbs predicted CV mortality	Bays et al. [86]

OxLDL Abs DLH3	246 pts with coronary angiography	CV events: cardiac death, MI, PTCA, and CABG	76 CV events	38 months	OxLDL predicted CV events	Shimada et al. [87]

AutoAbs MDA-oxLDL	734 IHD pts	CV mortality, MI, ACS, and CV events	65 CV deaths, 153 CV events	7.2 years	OxLDL predicted CV death and events	Maiolino et al. [81]

AutoAbs Cu-oxLDL	74 PTCA pts, 14 ctr	Restenosis	34 restenosis	6 months	AutoAbs predicted restenosis	Lee et al. [107]

OxLDL Abs DLH3	102 primary PTCA pts, 86 ctr	Restenosis	25 restenosis	6 months	OxLDL predicted restenosis	Naruko et al. [89]

OxLDL Abs 4E06	433 ACS pts	CV death, MI	17 CV deaths, 57 MI	2 years	OxLDL predicted MI	Johnston et al. [91]

OxLDL Abs FOH1a/DLH3	84 CHF pts (EF < 45%), 18 ctr	CV death, CV hospitalization, and fatal arrhythmia	26 CV events	780 days	OxLDL predicted CV events	Tsutsui et al. [83]

Abs: antibodies; ACS: acute coronary syndrome; AutoAbs: autoantibodies; CABG: coronary artery by-pass surgery; CHF: congestive heart failure; Crt: controls; CV: cardiovascular; ESRD: end-stage renal disease; IHD: ischemic heart disease; IMT: intima-media thickness; MI: myocardial infarction; oxLDL: oxidized low-density lipoproteins; OxPL/apoB: oxidized phospholipids on apolipoprotein B-100; PTCA: percutaneous transluminal coronary angioplasty; pts: patients.