Research Article

The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF- B Activation

Figure 4

Lidocaine treatment inhibits HMGB1 mRNA expression in multiple organs of CLP-induced septic rats. Rats were treated with NS or lidocaine 10 h after CLP. Liver, kidneys, lungs, and ileum were collected 24 h after CLP. HMGB1 mRNA expression in various organs were measured by Real-Time PCR. Data were presented as mean ± SD ( ). versus Sham; versus NS; versus Lido3 mg/kg; versus Lido6 mg/kg; NS: normal saline; Lido: lidocaine.
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