Research Article

The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF- B Activation

Figure 3

Lidocaine treatment decreases of systemic HMGB1 release in CLP-induced septic rats. (a) Time course of changes in serum HMGB1 levels. Serum from rats with or without CLP was collected at various time points (0, 2, 4, 8, 16, 24, 48, and 72 h after CLP). Serum HMGB1 levels were measured by ELISA. Data were presented as mean ± SD ( ). versus Sham. (b) Serum from rats subjected to CLP treated with NS and rats subjected to CLP treated with lidocaine 3, 6, and 9 mg/kg at 24 h after CLP. Serum HMGB1 levels were measured by ELISA. Data were presented as mean ± SD ( ). versus NS; versus Lido3 mg/kg. NS: normal saline; Lido: lidocaine.
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