The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-B Activation
Figure 1
Lidocaine treatment protects acute organ injury induced by CLP. Rats were treated with NS or lidocaine 10 h after CLP. Serum, liver, kidneys, lungs, and ileum were collected 24 h after CLP. Plasma contents of ALT (a) and creatinine (b), activity of MPO in lungs (c), and DAO in ileum (d) were measured. Data were presented as mean ± SD (). versus Sham; versus NS; versus Lido3 mg/kg; versus Lido6 mg/kg. (e) Hematoxylin and eosin stained sections of liver, kidneys, lungs, and ileum from rats subjected to Sham and to CLP treated with NS and rats subjected to CLP treated with lidocaine 9 mg/kg at 24 h after CLP. Original magnification: ×400. NS: normal saline; Lido: lidocaine.