PGD Synthase and PGD₂ in Immune Resposne

Table 1

Summary of PGDS and PGD₂ effects in models of inflammation.

	Model	Reference
H-PGDS
Proinflammatory	Allergic airway inflammation; (mouse model)	[18]
Anti-inflammatory	Delayed type hypersensitivity; (mouse model)	[24, 25]
L-PGDS
Pro-inflammatory	Allergic airway inflammation; (mouse model)	[40]
	Chronic allergic dermatitis; (mouse model)	[41]
	Human ulcerative colitis	[42]
	Diabetic nephropathy; (mouse Model)	[43–45]
Anti-inflammatory	LPS-induced lung inflammation; (mouse model)	[33]
Immunoprotective	P. aeruginosa lung inflammation; (mouse model)	[33]
PGD2
Pro-inflammatory	Asthma and allergic airway inflammation; (mouse model)	[40, 47]
	Neuroinflammation/Krabbe’s disease; (mouse Model)	[48]
	Skin inflammation; (mouse model)	[49]
Anti-inflammatory	Mouse model of pleuritis	[3]
	Mouse model of colitis	[50]
Immunosuppressive	Viral infection; (mouse Model)	[51]