Research Article
Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)
Table 2
Number of rats exhibiting the different pathology scores observed in endocrine (A) and exocrine (B) pancreas.
| A-Endocrine pancreas lesions |
| Evaluated | Inflammatory | Fibrosis | Intra islet | Congestion | parameters | Infiltrate | | | | | Vacuolation | | | | | Score | 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 |
| Groups (, each) | | | | | | | | | | | | | | | | |
| ZDF (+/+) vehicle | 7 | 1 | 0 | 0 | 6 | 2 | 0 | 0 | 8 | 0 | 0 | 0 | 8 | 0 | 0 | 0 | ZDF (fa/fa) vehicle | 0 | 0 | 5 | 3 | 0 | 1 | 1 | 6 | 2 | 0 | 6 | 0 | 7 | 0 | 1 | 0 | ZDF (fa/fa) sitagliptin | 1 | 7 | 0 | 0 | 0 | 5 | 3 | 0 | 4 | 3 | 1 | 0 | 8 | 0 | 0 | 0 |
| B – Exocrine pancreas lesions |
| Evaluated | Inflammatory | | | Fibrosis | | | Congestion | parameters | Infiltrate | | | | | | | | | | | | | Score | 0 | 1 | 2 | 3 | | | 0 | 1 | 2 | 3 | | | 0 | 1 | 2 | 3 |
| Groups (, each) | | | | | | | | | | | | | | | | |
| ZDF (+/+) vehicle | 8 | 0 | 0 | 0 | | | 7 | 1 | 0 | 0 | | | 8 | 0 | 0 | 0 | ZDF (fa/fa) vehicle | 0 | 3 | 5 | 0 | | | 0 | 3 | 3 | 2 | | | 2 | 6 | 0 | 0 | ZDF (fa/fa) sitagliptin | 0 | 4 | 4 | 0 | | | 6 | 1 | 1 | 0 | | | 4 | 4 | 0 | 0 |
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ZDF, Zucker diabetic fatty.
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