Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial Ischemia/Reperfusion Injury
Figure 3
SPC inhibits apoptosis of cardiomyocytes in vitro and in the infarction in vivo. (a) Quantification of TUNEL-positive nuclei in rat neonatal cardiomyocytes after simulated ischemia/reperfusion in the presence or absence of 10 μM SPC. (b) Representative terminal dUTP nick end-labeling (TUNEL) staining in the area at risk (outside the TTC-positive area) of control and SPC-treated mice 24 hours after ischemia/reperfusion. Morphometric quantification is presented above.
