Disease Gene expression in affected tissue Tissue Array type References SLE OASL ↑, LY6E ↑, MX1 ↑, PRKR ↑, ICAM1 ↑, SCYA3 ↑, XIAPAF1 ↑, LCK ↓ , TCR
↓ , CD1C ↓ PBMC of control and SLE patients U95A microarray, Affymetrix [54 ] TNFSF10 ↑, TNFSF10C ↑, TNFSF10D IL-1
↑, IL-1
↑, IL1R2 ↑, IL1RAP ↑, IL-8 ↑, CXCR1 ↑, CXCR2 ↑, Fcγ R1 ↑, IL-16 ↓ , CCR7↓ PBMC of control and SLE patients cDNA microarray, 375 cytokine-/ chemokine-related cDNAs [51 ] TRIP14 ↑, OAS1 ↑, TAP1 ↑, TRAIL ↑, MX1 ↑, MX2 ↑, XIAPAF1 ↑, IFIT4 ↑, MCP-1 ↑, DC-LAMP ↑, TCR
↓ , DAP3 ↓ PBMC of SLE patients and controls U95A microarray, Affymetrix, 12 600 probes sets [55 ] IFN-
↑, IFIT1 ↑, IFIT2 ↑, IFIT4 ↑, OAS1 ↑, OAS2 ↑, OASL ↑, LY6E ↑, TCR
↓ , TCR
↓ PBMC of SLE patients and controls U95A microarray, Affymetrix, 12 600 probes sets [56 ] Psoriasis S100A2 ↑*) , S100A7-A9 ↑, IL-8 ↑, DEFB2 ↑, CD68 ↑, CD47 ↑, ECGF1 ↑, ANXA1 ↑, KRT15 ↓ , MT1L ↓ Normal, univolved and involved skin U95A microarray, Affymetrix, 12 600 probes sets [57 ] S100A7 ↑, S100A9 ↑, S100A12 ↑, FABP5 ↑, DEFB2 ↑, MMP12 ↑, CD47 ↑, STAT1 ↑, TNXA ↓ , TIMP3 ↓ Univolved and involved skin HuGeneFL microarray, Affymetrix, 7 000 probe sets [58 ] S100A7-A9 ↑, IL-8 ↑, ECGF1 ↑, PBEF ↑, STAT1 ↑, SCYA2 ↑, SCYA19 ↑, SCYA21 ↑, SDF ↑, CDKN1C ↓ , SCYA27 ↓ , ITGB1 ↓ Normal, univolved and involved skin U95A-E microarrays, Affymetrix, 63 000 probe sets [59 ] SSc CALR ↑, COL15A1 ↑, NID2 ↑, CTGF ↑, FKBP1A ↑, CDH5 ↑, CD14 ↑, CD31 ↑, FGF7, FGFR1, SCYA19 ↑,THY1 ↑, CD53 ↑, IGHG3 ↑, BMP10 ↓ , WIF-1 ↓ Involved, uninvolved and normal skin U95A microarray, Affymetrix, 12 625 probes sets [60 ] CENPE ↑, CDC7 ↑, CDT1↑, FGF5↑, TNFRSF12A ↑, TRIP ↑, NICN1 ↑, SYT6 ↑, SMAD1 ↓ , IL-15 ↓ , CXCL5 ↓ , FBLN 1 and 2 ↓ Different subtypes of SSc patients Oligonucleotide microarrays, 44 000 probes, Agilent Technologies [61 ] COLA7 ↑, COLA18 ↑, CD44 ↑, MT1A ↑, MT1B ↑, MTIX ↑, DSP ↑, PDGFC ↑, FGFRL1 ↑, VEGFB ↓ , SGK ↓ , PTX3 ↓ Fibroblast cultures of SSc patients and controls Spotted oligonucleotide microarrays, 16 600 probes [62 ]
