Purpose. To study the protecting effects of dexamethasone on thymus of rats with
severe acute pancreatitis (SAP).
Methods. The SAP rats were randomly assigned to the model group and
dexamethasone-treated group, the other normal healthy rats were assigned to the sham operation
group. The rat survival, thymus pathological changes, apoptotic index, as well as expression
levels of NF-κB, P-selectin, Bax, Bcl-2, and Caspase-3 protein of all groups were
observed, respectively, at 3 hours, 6 hours, and 12 hours. The contents of amylase and endotoxin in plasma
as well as the contents of TNF-α, PLA2, and NO in serum were determined.
Results. There was no marked difference between the model group and treated group
in survival. The contents of different indexes in blood of treated group were lower than those of the model
group to various degrees at different time points. The thymus pathological score was lower in treated group
than in model group at 12 hours.The treated group in Caspase-3 protein expression of thymus significantly
exceeded the model group at 12 hours. The apoptotic index was significantly higher in treated group than
in model group. Conclusion. Dexamethasone has protecting effects on thymus of SAP
rats.