| | S. number | Name of the compound | Isolated from | Nature of origin | Mechanism of inhibition of Hsp90 | Signaling protein downregulated by Hsp90 inhibitors | References |
| | 1 | Geldanamycin | Streptomyces hygroscopicus | Bacterial | Binds to N-terminal domain of Hsp90 | ↓ c-Raf,
↓ Akt,
↓ BCR-
ABL | [74] |
| | 2 | Radicicol | Diheterospora chlamydosporia and Monosporium bonorden | Fungal | Binds to N-terminal domain of Hsp90 | ↓ p-Raf1,
↓ p-BCR-
ABL | [90] |
| | 3 | Novobiocin | Streptomyces spheroids | Bacterial | Binds to C-terminal domain of Hsp90 | ↓ p-Akt,
↓ p-ERK &
↓ p-BCR-
ABL | [91, 92] |
| | 4 | Epigallocatechin-3-gallate | Camellia sinensis | Plant | Binds to C-terminal domain of Hsp90 | ↓ CyclinD1,
↓ CDC25A | [96] |
| | 5 | Taxol | Taxus baccata L. | Plant | NYK | ↓ pSTAT3,
↓ pSTAT5,
↓ p-CRKL,
↓ p-Lyn | [101] |
| | 6 | Gambogic acid | Garcinia hanburyi | Plant | Binds to N-terminal domain of Hsp90 | ↓ p-BCR-
ABL
↓ pSTAT5,
↓ p-CRKL,
↓ pERK1/2,
↓ p-Akt &
↓ p-BCR-
ABL | [103, 104] |
| | 7 | Celastrol | Tripterygium wilfordii Hook F | Plant | Disrupts binding of Cdc37 to Hsp90 | ↓ pSTAT5,
↓ p-CRKL,
↓ pERK1/2,
↓ p-Akt,
↓ p-BCR-
ABL,
↓ Bcl-xL,
↓ Mcl-1,
↓ survivin | [107, 108] |
| | 8 | Curcumin | Curcuma aromatica, Curcuma longa, and Curcuma phaeocaulis | Plant | NYK | ↓ BCR-
ABL,
↓ CRKL,
↓ STAT5 | [110, 111] |
| | 9 | Withaferin A | Withania somnifera | Plant | Disrupts the binding of Cdc37 to Hsp90 | ↓ NFκB,
↓ Bcl-2,
↓ Bim,
↓ p-Bad | [114, 115] |
| | 10 | 5-Episinuleptolide acetate | Sinularia species | Coral | NYK | ↓ c-ABL,
↓ Akt,
↓ NFκB | [116] |
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