Research Article

Subcutaneous Implants of Buprenorphine-Cholesterol-Triglyceride Powder in Mice

Table 1

Summary of experimental design: histopathology phase.

Test or control articleTotal weight administeredNumber of dosesDays on testNumber of animals

Saline0.005 mL145♂, 5♀
Long acting drug powder3 mg 145♂, 5♀
Long acting drug powder15 mg145♂, 5♀
Saline0.015 mL3125♂, 5♀
Long acting drug powder9 mg3125♂, 5♀
Long acting drug powder45 mg3125♂, 5♀