Pretransplant Donor-Specific Anti-HLA Antibodies and the Risk for Rejection-Related Graft Failure of Kidney Allografts

Table 5

Univariate and multivariate Cox regression analysis for overall graft loss and ABMR-related graft loss after the first year of transplantation.

	Graft loss after first year (184 events)			ABMR-related graft loss (52 events)
Univariate analysis for graft loss	value	Hazard ratio	95% CI	value	Hazard ratio	95% CI
Male sex recipient	0.99	1.00	0.75–1.34	0.81	1.06	0.62–1.84
Age recipient (per year)	0.009	0.98	0.98–0.99	0.052	0.98	0.91–1.00
Age donor (per year)	0.013	1.01	1.00–1.03	0.13	1.02	0.99–1.036
Deceased donor kidney	0.014	1.43	1.07–1.92	0.37	1.28	0.74–2.20
Previous transplant	0.010	1.56	1.11–2.19	0.024	1.99	1.09–3.63
Number of HLA mismatches	0.94	1.00	0.91–1.10	0.23	0.89	0.75–1.70
PRA current pos	0.096	1.30	0.95–1.77	0.14	1.52	0.86–2.67
PRA peak serum pos	0.54	0.90	0.65–1.25	0.50	1.25	0.64–2.44
DSA present	0.024	1.45	1.05–2.01	0.011	2.09	1.18–3.71
DSA deceased donor kidney	<0.001	2.12	1.46–3.07	<0.001	3.39	1.83–6.25
Multivariate analysis for graft loss
Age donor (per year)	0.001	1.02	1.01–1.03	—	—	—
Age recipient (per year)	0.001	0.98	0.97–0.99	0.051	0.98	0.96–1.00
DSA deceased donor kidney	0.035	2.14	1.06–4.35	0.017	4.94	1.32–18.43

Interaction term for variables.