Pretransplant Donor-Specific Anti-HLA Antibodies and the Risk for Rejection-Related Graft Failure of Kidney Allografts
Table 3
Univariate and multivariate Cox regression analysis for graft loss and rejection in the first year after transplantation.
value
Hazard ratio
95% CI
Univariate analysis for graft loss first year (45 events)1
Male sex recipient
0.98
1.01
0.56–1.81
Age recipient (per year)
0.57
0.99
0.97–1.02
Age donor (per year)
0.005
1.03
1.01–1.06
Deceased donor kidney
<0.001
7.32
3.10–17.3
Previous transplant
0.23
1.51
0.77–2.98
Number of HLA mismatches
0.14
1.15
0.95–1.39
PRA current
0.11
1.63
0.89–2.96
PRA peak serum
0.69
0.88
0.46–1.67
DSA present
0.009
2.22
1.22–4.06
DSAdeceased donor kidney
0.56
1.96
0.21–18.45
Multivariate analysis for graft loss first year
DSA present
0.042
1.88
1.02–3.44
Age donor
0.003
1.04
1.01–1.06
Deceased donor kidney
<0.001
6.91
2.91–16.39
Univariate analysis for ABMR within first year (12 events)
Male sex recipient
0.72
1.24
0.39–3.89
Age recipient (per year)
0.63
1.01
0.97–1.05
Age donor (per year)
0.87
1.00
0.96–1.04
Deceased donor kidney
0.79
1.17
0.38–3.62
Previous transplant
0.49
1.58
0.43–5.84
Number of HLA mismatches
0.23
1.25
0.87–1.78
PRA current
0.48
1.01
0.99–1.03
PRA peak serum
0.37
1.01
0.99–1.03
DSA present
0.001
7.70
2.32–25.57
DSAdeceased donor kidney
0.64
0.57
0.051–6.23
1Numbers of events are graft losses censored for death with functioning graft. Total graft loss within the first year is 70. Interaction term for variables.
