Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?

Figure 1

Survivin gene and protein structure. (a) The position of the gene and the relevant protein product with 3D dimer structure (base on PDB accession No.1e31) are shown. p53 protein plays an inhibitory role in the gene transcription. (b) The linear schematic structure of the survivin protein is shown along with the domains and roles of each. A BIR domain with antiapoptotic activity and an extended c-terminal alpha-helix region involved in protein interactions and nuclear exportation.

(a)

(b)