Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function

Table 3

Results of the final linear mixed model for dependent variable ln(uNGAL) (𝑛=171 observations derived from 40 patients).

	Coefficient estimate	P value	95% CI
Intercept	5.46	<0.001	4.94	5.98
Graft function
DGF = 0 (prompt graft function)	−2.04	<0.001	−2.64	−1.44
DGF = 1 (with DGF-reference)	0	—	—	—
Time
Time (3 to 6 h after surgery)	0.47	0.088	−0.07	1.00
Time (1st day)	0.94	0.001	0.41	1.47
Time (2nd day)	1.01	<0.001	0.49	1.53
Time (4th day)	1.02	<0.001	0.50	1.54
Time (7th day-reference)	0	—	—	—
Time * DGF
Time (3 to 6 h after surgery) * DGF = 0	1.40	<0.001	0.68	2.13
Time (1st day) *  DGF = 0	0.40	0.257	−0.29	1.10
Time (2nd day) *  DGF = 0	−0.37	0.295	−1.06	0.32
Time (4th day) * DGF = 0	−0.73	0.039	−1.42	−0.03
Time (7th day) * DGF = 0 (reference)	0	—	—	—
Time on dialysis	0.076	0.003	0.03	0.12

Abbreviations: uNGAL: urinary neutrophil gelatinase associated lipocalin; ln: natural logarithm; DGF: delayed graft function (DGF = 0, no delayed graft function).