Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function
Table 1
Summary of baseline and clinical characteristics in kidney transplant donors and recipients (total sample and categorized by delayed or prompt graft function).
Total ()
DGF ()
Non-DGF ()
value
Donor
Age (yr)
0.172
Male gender
26 (65)
14 (78)
12 (54.5)
0.125
Living donor
11 (27.5)
3 (16.7)
8 (36.4)
0.165
Expanded criteria donors
3 (7.5)
1 (5.6)
2 (9.1)
0.541
Serum creatinine (mg/dL)
0.81 ± 0.18
0.85 ± 0.21
0.78 ± 0.16
0.318
Donor-recipient
HLA mismatches
0.941
Cold ischemia time (h)
0.035*
Living donor
0.204
Deceased donor
0.088
Recipient
Age (yr)
0.006*
Male gender
26 (65)
11 (61)
15 (68)
0.641
Caucasian
40 (100)
18 (100)
22 (100)
—
BMI (Kg/m2)
0.091
Previous transplant
2 (5)
0 (0)
2 (9.1)
Time on dialysis (yr)
0.135
Pretransplant therapy
Dialysis
38 (95)
18 (100)
20 (90.9)
0.296
Preemptive transplantation
2 (5)
0 (0)
2 (9.1)
Cause of kidney disease
IgA nephropathy
7 (17.5)
2 (11.1)
5 (22.7)
—
Glomerulonephritis
6 (15.0)
4 (22.2)
2 (9.1)
—
Diabetic nephropathy
5 (12.5)
3 (16.7)
2 (9.1)
—
Autosomal dominant polycystic kidney disease
3 (7.5)
3 (16.7)
0 (0)
—
Unknown
4 (10.0)
1 (5.6)
3 (13.6)
—
Others
15 (37.5)
5 (27.8)
10 (45.5)
—
Peak PRA (%)
0.853
0
29 (72.5)
14 (77.8)
15 (68.2)
—
1–25
8 (20.0)
3 (16.7)
5 (22.7)
—
26–75
3 (7.5)
1 (5.6)
2 (9.0)
—
Current PRA (%)
0.585
0
34 (85)
15 (83.3)
19 (86.4)
—
1–25
5 (12.5)
2 (11.1)
3 (13.6)
—
26–50
1 (2.5)
1 (5.6)
0 (0)
—
Induction regimen
Antithymocyte globulin (ATG-F)
4 (10)
1 (5.6)
3 (13.6)
0.613
Basiliximab/daclizumab
30 (75)
14 (77.8)
16 (72.7)
0.789
Immunosuppression at time of discharge
Steroids
38 (95.0)
18 (100)
20 (90.9)
0.296
Tacrolimus
38 (95.0)
17 (94.4)
21 (95.5)
0.886
Cyclosporine A
2 (0.05)
1 (5.6)
1 (5.6)
0.884
Values are expressed as mean ± standard deviation or absolute numbers and percentages. Comparisons between continuous variables were done using parametric (-test) or nonparametric (Mann-Whitney) tests; associations between categorical variables were analyzed using the test and Fisher’s exact test as appropriate; . Abbreviations: HLA: human leukocyte antigen; BMI: body mass index; PRA: panel reactive antibody.