Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
Figure 5
Photomicrographs of kidney from a diabetic rat into which embryonic pig pancreas had been transplanted in mesentery, and pig islets had been transplanted subsequently in kidney stained using anti-insulin antibody (a, c) or control antibody (b, d) and sections hybridized to antisense (e) or sense (f) porcine proinsulin mRNA probes. Arrowheads delineate an expanded subcapsular space (a, b). Arrows delineate tissue in the subcapsular space that stains positive for insulin (red-brown) (c) or positive staining for porcine proinsulin mRNA (e). PT, proximal tubule (a, b). Scale bars 80 um (a, b) and 10 um (c–f), reproduced with permission from the American Society for Investigative Pathology [12].
