Beneficial Effects on Pregnancy Outcomes of Thyroid Hormone Replacement for Subclinical Hypothyroidism
Table 3
Pregnancy outcome with any raised antibody and with TSH < 2.5 mIU/L.
Variable
No positive antibody
≥1 positive antibody
value
Odds ratio
LC
UC
()
()
%
%
TGAb > 60 IU/mL
0
0.0%
111
58.1
NA
TPOAb > 60 IU/mL
0
0.0%
141
73.8
NA
GTT positive (GD)
28
3.8%
7
3.7
0.956
1.0
0.4
2.3
Nulliparous
281
38.2%
62
33.5
0.236
0.8
0.6
1.1
APGAR 1 minute < 7
24
3.3%
8
4.3
0.495
1.3
0.6
3.0
APGAR 5 minutes < 7
5
0.7%
2
1.1
0.582
1.6
0.3
8.2
Fetal death in utero (FDIU)
3
0.4%
2
1.1
0.274
2.6
0.4
15.8
Stillbirth or FDIU
10
1.4%
3
1.6
0.807
1.2
0.3
4.3
Pregnancy induced hypertension
15
2.0%
3
1.6
0.694
0.8
0.2
2.7
Premature labour
13
1.8%
3
1.6
0.817
0.9
0.3
3.2
Antepartum haemorrhage
3
0.4%
2
1.1
0.274
2.6
0.4
15.8
Abruption
1
0.1%
0
0.0
NA
SROM
18
2.4%
1
0.5
0.990
0.2
0.0
1.6
SGA
10
1.4%
4
2.1
0.443
1.6
0.5
5.1
TSH, thyroid stimulating hormone; TGAb, anti-thyroglobulin antibodies; TPOAb, thyroperoxidase antibodies; SROM, spontaneous rupture of membranes; SGA, small for gestational age; FDIU, fetal death in utero.
