TY - JOUR A2 - Yamada, Masanobu AU - Brenta, Gabriela PY - 2011 DA - 2011/09/19 TI - Why Can Insulin Resistance Be a Natural Consequence of Thyroid Dysfunction? SP - 152850 VL - 2011 AB - Evidence for a relationship between T4 and T3 and glucose metabolism appeared over 100 years ago when the influence of thyroid hormone excess in the deterioration of glucose metabolism was first noticed. Since then, it has been known that hyperthyroidism is associated with insulin resistance. More recently, hypothyroidism has also been linked to decreased insulin sensitivity. The explanation to this apparent paradox may lie in the differential effects of thyroid hormones at the liver and peripheral tissues level. The purpose of this paper is to explore the effects of thyroid hormones in glucose metabolism and analyze the mechanisms whereby alterations of thyroid hormones lead to insulin resistance. SN - 2090-8067 UR - https://doi.org/10.4061/2011/152850 DO - 10.4061/2011/152850 JF - Journal of Thyroid Research PB - SAGE-Hindawi Access to Research KW - ER -