Toxoplasma gondii Myocarditis after Adult Heart Transplantation: Successful Prophylaxis with Pyrimethamine
Figure 2
Photomicrographs of the myocardium in the necropsy. (a) In panoramic view, moderate to intense myocardial inflammation with edema and mononuclear cells is visible. Large Toxoplasma pseudocysts, indicated by the arrow, existed in a region without inflammatory infiltrate. This region is amplified in image (b). The inset shows amplification of the pseudocyst, with antibody specific for T. gondii highlighting the round corpuscles, which is consistent with the tachyzoites form of T. gondii. (b) The tachyzoites are still closed and hidden intracellularly. (c) A high magnification of the myocardium in an area of myocarditis. The infiltrate was composed of lymphocytes, plasma cells and histiocytes ((a), (b) and (c) Hematoxylin and eosin stain with objective ×10, ×100 oil and ×40, respectively; objective ×40 with digital zoom at the inset).
