State of the Science: Biologically Based Modeling in Risk Assessment
1National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA
2Department of Occupational and Environmental Health, University of Montreal, Montreal, QC, Canada
3National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA
State of the Science: Biologically Based Modeling in Risk Assessment
Description
Biologically based modeling has been a critical step in human risk assessment of pharmacologic and environmental chemical exposures. Physiologically Based Pharmacokinetic (PBPK) models are used for predictions of an internal or target dose from external exposures. However, each risk assessment is dependent on the nature of the animal and human databases to support extrapolations across species, experimental paradigms, and variability of response within human populations. With an increased emphasis on the development of computational toxicology models using paradigms farther removed from physiological exposures, whole organism responses, and long-term health outcomes, a challenge arises for the integration of the state-of- the-art science PBPK modeling with emerging and current risk assessment paradigms. We will take a particular interest in original manuscripts that highlight application of cutting-edge PBPK models and analyses that can provide the basis for future modeling efforts and provide bridges to emerging toxicology paradigms. Potential topics include, but are not limited to:
- Increased understanding of human variability of pharmacokinetics and pharmacodynamics in the population
- Exploration of rodent mode of action hypotheses
- Application of biological modeling in the risk assessment of individual and mixtures of chemicals
- Identifying and addressing uncertainties in the modeling process
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