Hepatic and Renal Toxicity Induced by TiO2 Nanoparticles in Rats: A Morphological and Metabonomic Study
Table 2
% of surface occupied by 4-HNE positive cells in liver parenchyma after 4 days
% of surface occupied by 4-HNE positive cells in liver parenchyma after 1 month
% of surface occupied by 4-HNE positive cells in liver parenchyma after 2 months
Controls
-
-
-
TiO2 0.5g/kg BW
-
-
-
TiO2 1g/kg BW
0.07 ± 0.03
0.05 ± 0.04
0.12 ± 0.03
TiO2 4g/kg BW
0.83 ± 0.34
0.78 ± 0.28
1.02 ± 0.45
TiO2 16g/kg BW
3.83 ± 1.04
4.25 ± 1.53
4.17 ± 1.67
% of area occupied by 4-hydroxynonenal (4-HNE) in liver parenchyma evaluated by morphometric analysis. Values indicate mean percentage ± standard deviation (SD).
