Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

Figure 2

Levels of titanium (μg/g of tissue) measured by inductively coupled plasma atomic emission spectroscopy (ICP-AES) inside renal and hepatic tissues from control and treated animals, sacrificed after 4 days, 1 month, and 2 months. Values are presented following a semilogarithm graph. The mean of values recorded in each group is specified in the table under the graph. Each measure was performed in triplicate. Data are mean ± SE (n=5). Significantly different from control ( p≤0.05; p≤0.001). Significant difference 1 month versus 4 days (# p≤0.05) and 2 months versus 1 month (◊ p≤0.05).