Journal of Toxicology / 2018 / Article / Tab 6 / Research Article
An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp Table 6 Summary of selected
clinical chemistry findings in the 14-day repeated oral toxicity study.
Group ALT GGT ALP TBIL CREA Pi Na+ ALB (mg/kg bw/day) U/L U/L U/L μ mol/Lμ mol/Lmmol/L mmol/L mmol/L mmol/L Male (main groups, = 5 each, except 3000 mg/kg bw/day group, = 2) Control 49.74 ± 6.56 0.30 ± 0.46 233.00 ± 51.06 2.25 ± 0.43 21.66 ± 1.45 2.69 ± 0.23 142.80 ± 1.48 102.70 ± 0.58 34.14 ± 0.84 1000 58.00 ± 8.98 1.92 ± 0.68∗∗ 182.60 ± 31.83 1.79 ± 0.21 20.96 ± 1.38 2.34 ± 0.36 142.40 ± 1.14 102.88 ± 0.64 33.86 ± 0.67 2000 79.10 ± 30.74 11.94 ± 4.60∗∗ 312.80 ± 54.34 4.09 ± 1.15∗∗ 20.78 ± 1.48 2.55 ± 0.24 142.40 ± 1.14 102.70 ± 1.06 33.80 ± 1.49 3000 140.70 ± 83.72 29.80 ± 14.00 452.00 ± 84.85∗∗ 16.27 ± 11.79 18.70 ± 0.00 2.43 ± 0.01 140.50 ± 2.12 102.05 ± 0.92 31.45 ± 3.89 Historical range♮ 26.5–87.9 0.0–1.2 111–316 1.01–2.69 17.2–31.1 2.20–3.10 136.0–145.0 99.7–106.2 31.8–36.8 Female (main groups, = 5 each, except 3000 mg/kg bw/d group, = 3) Control 44.82 ± 8.55 1.72 ± 0.26 119.60 ± 15.44 1.96 ± 0.23 21.30 ± 1.74 2.38 ± 0.23 142.60 ± 0.89 103.66 ± 0.56 34.64 ± 0.47 1000 67.82 ± 23.86 5.32 ± 2.03∗∗ 135.00 ± 32.14 2.01 ± 0.20 20.50 ± 2.28 2.32 ± 0.25 142.40 ± 0.55 104.14 ± 1.92 33.92 ± 0.67 2000 87.92 ± 16.57∗∗ 16.76 ± 4.09∗∗ 234.00 ± 54.18∗∗ 4.34 ± 2.25∗∗ 17.58 ± 1.38 2.57 ± 0.23 141.20 ± 2.95 102.74 ± 2.64 33.76 ± 0.42 3000 76.93 ± 18.50 41.80 ± 30.45 228.67 ± 78.49∗∗ 6.16 ± 2.11 13.93 ± 3.46∗∗ 2.98 ± 0.44 144.67 ± 1.15 107.47 ± 2.65 32.00 ± 2.69 Historical range 21.3–74.2 0.1–3.3 53–194 0.89–2.26 19.4–37.3 1.71–3.13 137.0–145.0 101.6–107.9 32.4–38.5
Data represent the mean values and the standard deviation.
: only parameters with statistically significant findings are shown in table.
††: dose was reduced from 4000 to 3000 mg/kg bw/d on day 2.
and ∗∗
P < 0.01, significance determined with Duncan's multiple range test or with Mann–Whitney
test versus control.
: minimum and maximum levels reported as the range of historical control values.