An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp

Table 15

Summary of notable histopathology findings in the 90-day repeated oral toxicity study.

Organs	Observations	Dose groups (mg/kg bw/day)
		Control		100	360	720
		Main	Recovery			Main	Recovery
Male
Adrenal gland	Increased cytoplasmic vacuolation	0/10	0/5	0/10	0/10	6/10	0/5
Kidney	Cyst	1/10	0/5	0/1	/	0/10	0/5
	Mineral deposits	0/10	0/5	1/1	/	0/10	0/5
Lungs	Alveolar emphysema	0/10	0/5	/	/	1/10	1/5
	Alveolar histiocytosis	2/10	0/5	/	/	1/10	0/5
Female
Adrenal gland	Increased cytoplasmic vacuolation	0/10	0/5	0/10	0/10	8/10	0/5
Kidneys	Focal fibrosis	0/10	0/5	1/1	0/1	0/10	0/5
Lungs	Alveolar emphysema	1/10	0/5	/	/	0/10	1/5
	Acute hemorrhage	0/10	1/5	/	/	0/10	0/5
	Alveolar histiocytosis	1/10	0/5	/	/	3/10	0/5
Uterus	Dilatation	4/10	3/5	/	/	2/10	1/5

/, not examined.
Data represent the number of animals with observation per number of animals observed.