Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats

Table 3

Histopathological findings in livers of treatment with antifungal agents.

Histological findings in the liver
Treatment group	Hepatocyte degeneration	Necrosis	Inflammation	Bile duct hyperplasia and granuloma
Ketoconazole	+++	+++	+++	++
Fluconazole	+++	+++	+++	+++
Itraconazole	++	++	++	+
Griseofulvin	+	+	+	+
Terbinafine	+	+	+	++

Normal (<4 lesions); + mild (4–7 lesions); ++ moderate (8–11 lesions); +++ severe lesions (≥12 lesions per slide); inflammation was determined based on the presence of macrophages and scattered neutrophils and eosinophils in central venules.