Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats

Table 2

Effect of the five oral antifungal agents (griseofulvin, fluconazole, ketoconazole, itraconazole, and terbinafine) on serum activities of AST, ALT, and ALP in rats after 28 days of treatment.

Groups	AST/IU mean ± SEM	ALT/IU mean ± SEM	ALP/IU mean ± SEM
Control	58.50 ± 5.40	60.17 ± 6.30	152.17 ± 5.57
Griseofulvin	172.83 ± 11.48	114.50 ± 6.06	418.17 ± 8.07
Fluconazole	323.67 ± 19.49	243.00 ± 16.43	566.33 ± 15.46
Ketoconazole	608.17 ± 24.78	400.00 ± 14.73	446.00 ± 14.13
Itraconazole	440.17 ± 12.98	296.67 ± 13.62	554.33 ± 24.40
Terbinafine	179.67 ± 13.89	105.83 ± 4.24	499.17 ± 16.77

AST: aspartate aminotransferase, ALT: alanine aminotransferase, and ALP: alkaline phosphatase
Tukey’s post hoc analysis: like letters (a–e) indicate nonsignificant differences.