Research Article

Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats

Figure 2

Photomicrographs of liver sections of the control group (a) and after 14- and 28-day courses of fluconazole (b), ketoconazole (c), itraconazole (d), terbinafine (e), and griseofulvin (f). (a) Normal lobulation with clear outlines, normal cells with visible outlines, and single nuclei. (b) In 14-day plate the rectangular area shows a marked reduction of cell numbers in the perivenular area. Circular areas indicate infiltration of venules by leukocytes. 28-day course plate shows reduced cellular density similar to 14-day plate. (c) Rectangular area indicates reduced cell density; circular areas indicate perivenular region with minor necrotic figures, that is, dark spots on plate. Triangular region indicates scattered necrotic foci (28-day course). (d) Minor venular distortion indicated by the circular demarcations here; triangular areas show apoptotic cells. Rectangular area shows reduced cell density. (e) Rectangular area shows paucity of cells; circular areas show clustering of cells which is a possible indication of stress. (f) Rectangular areas show a reduction in cell numbers and tissue striations (28 d). Perivenular cell paucity is indicated by the circular area on the plate (14 d). Also apparent are necrotic foci around the central venue (arrows). All plates are ×200 magnification.