A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine
Table 8
Summary of statistically significant clinical chemistry findings.
Dose group (mg/kg bw/d)
Males
Females
Control
180
300
375
Historical range
Control
180
300
375
Historical range
ALT (U/L)
54.97 ± 10.62
66.51 ± 7.29
73.55 ± 13.81
75.58 ± 18.09
38.5–98.0
58.26 ± 11.88
68.12 ± 12.14
73.925 ± 17.23
78.25 ± 14.91
31.4–84.1
AST (U/L)
94.64 ± 20.70
101.81 ± 12.75
98.25 ± 8.76
112.53 ± 17.90
72.6–123.5
95.25 ± 16.82
89.75 ± 16.20
99.39 ± 17.46
112.36 ± 20.00
75.0–116.6
ALP (U/L)
102.80 ± 20.47
78.8 ± 10.89
79.70 ± 12.28
89.44 ± 25.67
67–215
55.9 ± 17.25
72.90 ± 25.88
60.88 ± 35.45
73.40 ± 32.00
20–185
TBIL (μmol/L)
1.71 ± 0.23
1.69 ± 0.28
2.07 ± 0.37
2.09 ± 0.35
0.62–4.72
1.839 ± 0.45
1.44 ± 0.34
1.86 ± 0.38
1.85 ± 0.62
0.91–4.69
CREA (μmol/L)
28.70 ± 2.73
32.76 ± 3.97
34.35 ± 4.58
35.97 ± 2.89
23.1–37.0
29.3 ± 2.32
29.51 ± 3.28
30.30 ± 3.55
31.15 ± 3.06
25.9–38.2
Urea (μmol/L)
7.48 ± 0.91
7.20 ± 0.88
7.64 ± 0.86
7.64 ± 0.82
4.14–9.62
6.947 ± 0.71
7.19 ± 1.04
6.83 ± 0.85
7.08 ± 0.82
4.79–9.71
GLUC (μmol/L)
6.04 ± 0.52
5.99 ± 0.53
5.62 ± 0.43
5.35 ± 0.33
4.98–7.97
5.73 ± 0.49
5.71 ± 0.49
5.10 ± 0.80
4.53 ± 0.41
4.18–8.49
Pi (μmol/L)
1.90 ± 0.28
2.09 ± 0.25
2.09 ± 0.20
2.39 ± 0.24
1.40–2.06
1.275 ± 0.16
1.53 ± 0.16
2.12 ± 0.20
2.11 ± 0.39
1.3–2.1
Ca (μmol/L)
2.67 ± 0.08
2.58 ± 0.11
2.56 ± 0.09
2.63 ± 0.07
2.39–2.75
2.617 ± 0.06
2.55 ± 0.10
2.57 ± 0.07
2.54 ± 0.10
2.4–2.8
Na (μmol/L)
142.00 ± 1.05
140.00 ± 1.49
138.80 ± 1.14
138.67 ± 0.87
137–147
140.6 ± 0.97
139.90 ± 1.79
139.25 ± 1.58
138.50 ± 2.51
137–147
K (μmol/L)
4.41 ± 0.25
4.61 ± 0.39
4.23 ± 0.15
4.45 ± 0.26
3.62–5.31
3.921 ± 0.24
4.15 ± 0.21
4.28 ± 0.32
4.24 ± 0.45
3.6–4.4
Cl (μmol/L)
105.65 ± 0.98
103.4 ± 1.70
102.24 ± 0.98
102.46 ± 1.34
101.0–106.6
104.66 ± 0.74
103.56 ± 1.37
102.79 ± 1.15
102.79 ± 2.22
101.2–109.6
ALB (g/L)
34.21 ± 0.72
33.08 ± 0.88
32.03 ± 1.61
33.63 ± 1.19
31.5–36.7
35.77 ± 1.29
34.73 ± 1.10
34.76 ± 1.45
35.03 ± 2.04
32.9–41.1
TPROT (g/L)
62.59 ± 3.30
59.7 ± 2.44
57.37 ± 2.30
61.22 ± 2.70
55.5–70.6
64.76 ± 3.53
62.09 ± 2.60
62.65 ± 2.66
64.29 ± 5.17
57.6–79.3
Values are expressed as mean ± standard deviation. Historical Range based on data from 40 male and 38 female (19 females for BUN and Pi) Hsd.Brl.Han Wistar control rats aged 19-20 weeks. mg/kg bw/d, milligrams per kilogram body weight per day; U/L, units per liter; μmol, micromol; g, gram; , number of animals. < 0.05; < 0.01.
