A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine
Table 7
Summary of statistically significant hematological findings.
Dose group (mg/kg bw/d)
Males
Females
Control
180
300
375
Historical range
Control
180
300
375
Historical range
WBC (×109/L)
7.91 ± 0.97
7.69 ± 1.49
6.69 ± 1.79
8.13 ± 1.65
4.60–13.86
6.20 ± 1.81
5.63 ± 1.02
4.74 ± 0.98
6.57 ± 1.66
2.96–12.94
MONO (%)
2.82 ± 0.48
3.70 ± 0.85
2.62 ± 1.17
2.67 ± 0.68
0.6–4.1
2.09 ± 0.64
2.26 ± 0.31
2.51 ± 0.45
1.81 ± 0.48
0.4–3.1
EOS (%)
1.41 ± 0.40
1.04 ± 0.34
0.78 ± 0.20
0.69 ± 0.31
0.4–3.3
1.06 ± 0.43
0.78 ± 0.34
0.76 ± 0.32
0.52 ± 0.20
0.5–2.0
RBC (×1012/L)
9.51 ± 0.40
8.43 ± 0.48
8.31 ± 0.64
8.34 ± 0.33
6.20–10.26
8.67 ± 0.28
7.92 ± 0.40
8.01 ± 0.52
8.19 ± 0.67
7.61–9.31
HGB (g/L)
168.70 ± 5.93
162.00 ± 7.47
161.90 ± 10.84
163.67 ± 3.50
109–184
161.20 ± 3.77
154.60 ± 6.82
158.88 ± 9.49
165.20 ± 6.99
145–169
MCV (fL)
48.04 ± 1.40
52.96 ± 2.96
53.94 ± 2.15
54.17 ± 2.68
45.0–53.7
51.13 ± 2.09
54.18 ± 2.71
54.78 ± 2.15
55.14 ± 1.65
47.0–55.0
MCH (pg)
17.75 ± 0.41
19.24 ± 0.81
19.51 ± 0.57
19.66 ± 0.86
16.7–19.4
18.61 ± 0.62
19.54 ± 0.89
19.85 ± 0.56
20.25 ± 1.29
17.3–19.7
MCHC (g/L)
369.70 ± 4.40
363.70 ± 9.07
361.80 ± 5.92
362.89 ± 4.26
339–376
363.90 ± 5.90
360.60 ± 3.53
362.75 ± 5.50
367.20 ± 17.07
351–368
RET (%)
3.15 ± 0.30
3.67 ± 0.32
4.18 ± 1.72
3.94 ± 0.56
2.51–4.65
3.93 ± 0.49
4.14 ± 0.79
3.91 ± 0.63
4.36 ± 1.22
3.17–6.16
Values are expressed as mean ± standard deviation. Historical Range based on data from 40 male and 38 female Hsd.Brl.Han Wistar control rats aged 19-20 weeks. mg/kg bw/d, milligrams per kilogram body weight per day; L, liter; fL, femtoliters; pg, picograms; , number of animals; < 0.05 and < 0.01.
