A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine
Table 3
Summary of mean body weight gain.
Group (mg/kg bw/d)
Body weight gain (g) between days
Sum
0–3
3–7
7–10
10–14
14–17
17–21
21–24
24–28
28–35
35–42
42–49
49–56
56–63
63–70
70–77
77–84
84–89
0–89
Males
Control
Mean
21.2
23.8
6.7
19.8
10.4
17.4
8.3
13.4
14.4
18.1
16.0
12.8
7.8
10.1
8.7
5.1
1.0
215.0
SD
1.8
3.3
2.9
3.4
2.4
3.8
4.2
3.9
2.9
3.5
4.0
2.1
2.3
3.0
3.9
3.5
2.4
15.1
180
Mean
16.5
23.1
10.5
18.0
9.5
16.2
9.9
12.2
19.3
16.3
14.6
15.2
10.9
8.5
9.4
7.1
3.6
220.8
SD
5.2
3.9
2.5
3.8
3.8
3.4
4.7
3.6
6.2
3.9
4.7
4.1
3.3
4.1
3.1
3.6
3.7
22.9
SS
300
Mean
10.3
21.6
7.7
16.9
8.4
13.2
10.6
9.8
16.1
13.3
14.3
12.1
9.7
10.6
11.1
0.9
4.9
191.5
SD
7.1
4.6
4.5
6.6
3.4
2.6
4.2
3.2
4.5
9.8
3.6
2.6
3.1
3.6
2.5
8.3
6.2
30.5
SS
375
Mean
−1.7
22.7
10.0
15.9
10.5
15.3
9.3
9.4
11.9
12.1
12.3
10.9
7.0
9.8
10.8
5.2
7.9
181.9
SD
12.5
3.6
5.2
6.0
3.8
3.1
4.2
8.0
6.2
5.7
6.9
6.2
5.5
4.2
5.3
6.1
2.0
27.7
SS
10
10
10
10
10
10
10
10
10
10
9
9
9
9
9
9
9
9
Females
Control
Mean
10.9
13.0
6.9
9.4
5.2
7.0
4.4
6.2
11.6
6.1
5.9
6.5
0.7
5.6
5.7
3.8
2.2
111.1
SD
3.7
1.6
3.4
2.3
2.8
1.6
3.4
2.7
4.2
3.6
3.8
2.1
3.6
2.8
4.2
4.1
3.3
13.7
180
Mean
9.1
13.1
9.0
8.3
5.7
8.8
3.6
8.2
9.7
5.3
7.5
7.3
1.1
4.2
4.5
4.6
4.0
114.0
SD
3.1
3.7
4.6
2.0
5.1
4.2
2.0
3.8
4.4
3.8
4.6
2.7
2.8
3.4
4.6
5.1
3.8
14.5
300
Mean
6.7
14.3
7.8
8.8
6.7
9.1
4.5
8.7
9.6
8.3
8.0
4.3
7.2
2.1
8.1
2.4
2.4
118.5
SD
5.1
2.8
3.6
4.7
3.4
2.2
3.4
2.1
2.5
2.5
4.5
4.2
2.5
3.6
2.4
3.2
1.8
16.5
10
10
10
10
10
10
10
10
9
9
9
9
9
8
8
8
8
8
SS
375
Mean
5.0
12.8
10.0
12.3
6.1
6.4
6.5
7.9
9.5
7.1
9.2
4.7
4.5
3.5
6.6
3.2
5.2
120.5
SD
2.5
2.7
3.5
3.3
4.4
4.4
4.3
3.3
5.2
7.6
5.2
2.4
2.5
3.9
5.0
4.5
3.8
21.4
SS
mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; g, grams; SS, statistical significance; , number of animals. < 0.05; < 0.01. unless otherwise stated.