The Protective Effects of Nigella sativa and Its Constituents on Induced Neurotoxicity

Table 5

The protective effect of Nigella sativa and its constituents on oxidative stress.

Drug	Dose	Result	References
N. sativa	200 mg/kg	Increased the thiol content and reduced the level of MDA in hippocampus	[31]
NSO	0.048, 0.192, and 0.384 mg/kg	Significantly decreased the MDA level	[32]
N. sativa	200 and 400 mg/kg	Increased the time spent in target quadrant and delay time to enter the dark compared to the PTZ group	[33]
N. sativa	400 mg/kg	Increased the time spent in target quadrant, while reduced the time latency compared to the PTU group	[34]
TQ	2.5, 5, and 10 mg/kg	Decrease the MDA level compared with ischemic group	[32]
TQ	20 mg/kg	Decreased the incidence of lead acetate-induced pathological lesions	[35]
Carvacrol	50 mg/kg	Reduced infarct volume and also improved neurological deficits	[36]
Carvacrol	73 mg/kg	TOS, MDA, IL-1 β, and TNF- levels were decreased significantly while TAS was increased in comparison to the MTX group	[37]