Signaling Network Map of Endothelial TEK Tyrosine Kinase

Figure 1

A detailed map of TIE2 signaling. This is a manually drawn (using PathVisio) pictorial representation of the network of reactions annotated in NetPath. The topology of the molecules and their reactions from TIE2 to the transcription factors are derived from the experimental information obtained by the use of inhibitors, activators, mutants, and silencing approaches. Each node represents the molecules and the edges represent the relationships between them as provided in the figure legend.