Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?

Figure 3

ROS modulate cadherin-mediated cell-cell junctions. Rac1-induced ROS may function as signaling molecules to disrupt cadherin-based cell-cell adhesion through either inhibition or activation of regulatory tyrosine phosphatases and kinases, respectively, as well as by localized activation of IQGAP and small GTPases, leading to various biological responses, including cell migration and proliferation.