Review Article
Nucleic Acids in Human Glioma Treatment: Innovative Approaches and Recent Results
Table 2
MicroRNAs implicated in glioma.
| miRNA | Function | Location | Targets | Cluster |
| Oncomir | miR-21 | Inhibits apoptosis and promotes invasion | Chr 17 intergenic | TP53BP2 [44] DAXX [44] HNRNPK [44] RECK [46] TIMP3[46] PDC4 [47]
| | miR-221 | Promotes proliferation and invasion | Chr X intergenic | PTPμ [48] P27 [49]
| miR-221/222 | miR-222 | Promotes proliferation and invasion | Chr X intergenic | PTPμ [48] P27 [49] | miR-221/222 | miR-9 | Inhibits neural differentiation and induce proliferation | Chr 9 sense | CAMTA1 [50] REST [52] | |
| Tumor suppressor | miR-124 | Induces G0/G1 cell cycle arrest; induce differentiation of adult mouse neural stem cells | Chr 8 sense | CDK6 [53] | | miR-137 | Induces G0/G1 cell cycle arrest; induces differentiation of adult mouse neural stem cells | Chr 1 sense | CDK6 [53] | miR-137/2682 | miR-7 | Tumor suppressor; suppresses EGFR expression and independently inhibits Akt pathway | Chr 9 sense | EGFR [55] | | miR-128 | Inhibits cell proliferation by targeting Bmi-1 and E2F3a | Chr 2 sense | E2F3A BMI1 [56] | | miR-181 | Is downregulated and associated with poor prognosis | Chr 9 Sense antisense | unknown | miR-181a/b |
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