Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells
Figure 2
IGF-I mRNA and IGF-I peptide expression levels induced by -estradiol in UtLM cells. (a) IGF-I gene expression in UtLM cells following E2 treatment at 0 (control), 10 and 60 min, and 24 h and 48 h. (b) IGF-I protein expression in UtLM cells following E2 exposure at 0 (control), 10 and 60 min, and 24 h and 48 h. Inset: Negative control with normal mouse IgG. Representative of mean ± SEM from three independent experiments. * versus control.