Review Article
NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases
Table 2
Known or suspected dimerization/oligomerization domains in ALK fusion partners. Dimerization/oligomerization domains present ALK fusion partners that are postulated to mediate dimerization/oligomerization are indicated. With the exception of the basic domain of EML4-ALK, these domains have not been experimentally proven to mediate dimerization/oligomerization of the respective fusion proteins. The basic domain of EML4 also possesses a coiled-coil motif which is postulated to mediate dimerization.
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*
The MYH9 coiled-coil domain is truncated in the fusion protein and may not be functional. |