Functional Diversity of the Schistosoma mansoni Tyrosine Kinases
Table 1
Protein tyrosine kinase classification. Tyrosine kinases classified into ePK groups, families, and subfamilies followed the proposed hierarchy described elsewhere [7ā9]. RTK: receptor tyrosine kinase. CTK: cytoplasmic tyrosine kinase.
Type
Abbreviation
Family name
RTK
Alk
Anaplastic lymphoma kinase
Axl
Also known as TAM (Tyro3, Axl, Mer) after the three human members
CCK4
Colon carcinoma Kinase 4
DDR
Discoidin domain receptor kinase
EGFR
Epidermal growth factor receptor
Eph
Ephrin receptor
FGFR
Fibroblast growth factor receptor
InR
Insulin Receptor
Met
MET or MNNG HOS transforming gene
MUSK
Muscle-specific kinase
PDGFR
Platelet-derived growth factor receptor
Ret
Ret proto-oncogene
ROR
RAR-related orphan receptor
Tie
Tyrosine kinase with immunoglobulin-like and EGF-like domains
VEGFR
Vascular endothelial growth factor receptor
VKR
Venus flytrap kinase receptor
CTK
Abl
Abelson murine leukemia homolog
Ack
Activated Cdc42-associated tyrosine kinase
Csk
Src subgroup kinase which phosphorylates Src
Fak
Focal adhesion kinase
Fer
Fps/Fes related
Jak
Janus kinase
Lmr
Lemur kinase
Ryk
Rich protein kinase
Sev
Named after Drosophila sevenless, a receptor tyrosine kinase involved in eye cell fate determination