Considerations in Raman Spectroscopy for Real-Time API Concentration Measurement at Tablet Press Feed Frame

Figure 4

(a) Raman spectra of 10% APAP in only lactose (green), only MCC (blue) and in the mixture of MCC and lactose (yellow), (b) Raman spectra of 10% APAP in MCC at t = 0 minutes and t = 2 minutes, (c) surface plot of Raman spectra of 10% APAP in MCC showing bleaching over time, (d) Raman spectra of 10% APAP in MCC at t = 0 minutes and t = 2 minutes after SNV correction, and (e) surface plot of Raman spectra of 10% APAP in MCC after SNV correction.

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